Spectrin Isoforms
نویسندگان
چکیده
منابع مشابه
Spectrin isoforms in the mammalian retina.
Spectrin is a major component of the mammalian neuronal cytoskeleton. In the CNS, three isoforms of brain spectrin are known to exist: a cellular and dendritic isoform, (240/235E), related to neurons and glia; a cellular and axonal isoform, (240/235), related to neurons; and an isoform specific for astrocytes, (240/235A). In the present study, brain spectrins (240/235E) and (240/235) were local...
متن کاملSpectrin αII and βII isoforms interact with high affinity at the tetramerization site
Spectrin tetramers form by the interaction of two α–β dimers through two helices close to the C-terminus of a β subunit and a single helix at the N-terminus of an α subunit. Early work on spectrin from solid tissues (typified by αII and βII polypeptides) indicated that it forms a more stable tetramer than erythroid spectrin (αI–βI). In the present study, we have probed the molecular basis of th...
متن کاملIsoforms of Spectrin and Ankyrin Reflect the Functional Topography of the Mouse Kidney
The kidney displays specialized regions devoted to filtration, selective reabsorption, and electrolyte and metabolite trafficking. The polarized membrane pumps, channels, and transporters responsible for these functions have been exhaustively studied. Less examined are the contributions of spectrin and its adapter ankyrin to this exquisite functional topography, despite their established contri...
متن کاملOntogeny, compartmentation, and turnover of spectrin isoforms in rat central neurons.
A variant of a principal structural protein of erythrocytes, spectrin, is a major neuronal protein. Here we have examined the subcellular and regional distributions, subunit composition, ontogeny, and metabolism of spectrin in rat CNS. While all subcellular fractions, except the mitochondrial, expressed the previously characterized brain form of spectrin (fodrin, or alpha gamma-spectrin), limit...
متن کاملSegregation of two spectrin isoforms: polarized membrane-binding sites direct polarized membrane skeleton assembly.
Spectrin isoforms are often segregated within specialized plasma membrane subdomains where they are thought to contribute to the development of cell surface polarity. It was previously shown that ankyrin and beta spectrin are recruited to sites of cell-cell contact in Drosophila S2 cells expressing the homophilic adhesion molecule neuroglian. Here, we show that neuroglian has no apparent effect...
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 2011
ISSN: 0002-9173,1943-7722
DOI: 10.1309/ajcpsa5rnm9igfjf